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Pharmacological action

The effect of Nexium is observed in 60 minutes after the 20-40 mg Nexium dose administration. The repeated administration of 20 mg dose of the drug is accompanied with the decrease of the gastric secretion, due to the pentagastrin effect. The 90% gastric secretion is observed on the fifth day of the Nexium therapy.
The administration of 40 mg dose of Nexium is recommended for the reflux esophagitis treatment. It is also prescribed for the treatment of the ulcerative defects of the gastric mucosa and duodenum. In combination with the proper antibiotic it is a good drug for the Helicobacter pylori eradication (and turns to be effective in 90% of cases). buy ampicillin In case of complex ulcer treatment with Nexium there is no need to continue the antisecretory monotherapy after the discontinuation of antibiotic intake as a rule.
Nexium is also effective in case of peptic ulcers prevention alongside with the concomitant non-steroidal anti-inflammatory drugs therapy (the intake of Nexium is possible even in case patient follows the COX - 2 selective group inhibitors therapy).

Pharmacokinetics: Nexium is the acid-dependent drug. It is produced in the form of the coated beads intended for the intake. It is very well absorbed. —max in the blood plasma is reached in 60-120 minutes after the drug intake. The bioactivity of Nexium after one 40 mg dose intake is 64%, and in case of repeated intake it is increased up to 90%. Buy Premarin The absolute bioactivity of one 20 mg dose is 50% and 68 % correspondingly.
Plasma proteins bind 97% of the active agent. The Nexium intake together with food doesn't influence the antisecretory effect but makes the drug absorption slower. The half-life of the drug is 70 minutes after the second dose administration in 24 hours. Nexium is excreted by the kidneys and is not cumulated in the body in case of 1 dose intake within 24 hours. small loan Less part of the drug is excreted with the faeces. The drug metabolites don't influence the hydrochloric acid secretion. Less than 1% of the drug is excreted unchanged by the kidneys.

Indications for use: Nexium is as a rule prescribed in case of Zollinger-Ellison syndrome treatment, or as the symptomatic or anti-recurrent treatment of reflux esophagitis and as the etiologic therapy of the reflux esophagitis ulcer. It can be used as the part of the complex treatment for the Helicobacter pylori eradication in case of gastric ulcer or duodenum Buy Plavix no prescription ulcer (together with antibacterial drugs). Nexium can be recommended for the preventive therapy of the peptic ulcers in case of NSAIDs intake, or for the treatment of ulcers caused by the non-steroidal anti-inflammatory drugs.

Side effects: Nexium has some side effects on the central nervous system and peripheral nervous system, such as drowsiness, paresthesia, aggression, depression, irritability, insomnia, hallucinations or dizziness. The side effects of the drug on the digestive tract, such as candidiasis or stomatitis are also possible. As for the blood-vascular and blood formation systems Buy Zithromax, here the thrombocytopenia, leukopenia, pancytopenia or agranulocytosis can be observed. Nexium intake can also have some side effects on the liver, such as hepatitis, encephalopathy or hepatic failure. In relation of the musculoskeletal locomotor system, Nexium can cause muscular weakness and joint pains. There are also some Nexium side effects for the skin, such as rash, photosensitivity, alopecia or toxic epidermal necrolysis.

Contraindications: Nexium is not recommended to the children aged less than 12. It shouldn't be prescribed to the patients with hypersensitivity to the drug or to the patients, following Atazanavir treatment. As for the pregnant women, Nexium should be prescribed with great care. The drug is not recommended for the intake to the patients women in the period of lactation. zoloft no prescription
Nexium is the prescription drug. Before the start of Nexium treatment, you should consult your doctor first.

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